The Association between Serum Magnesium Level and Microalbuminuria in Diabetic Patients Attending Sebha Diabetic and Endocrine Centre, Sebha-Libya

Abstract

Background: Magnesium is one of the essential elements for various vital processes in the human
body and has an important role in glucose metabolism. Magnesium deficiency may play a role in
poor glycemic control and the development of diabetic complications.
Objective: This study aimed to investigate the potential association between magnesium
deficiency and elevated microalbuminuria levels.
Method: This study was conducted during the period from June 2023 to January 2024 at the
Diabetes and Endocrinology centre in Sabha-Libya. We studied 124 diabetic patients and 44
healthy individuals as controls in the Sebha Diabetic and Endocrine Centre. Blood samples were
collected for the analysis of Fasting Blood Sugar (FBS), hemoglobin A1c (HbA1C), lipid profile
(Triglyceride (TG), Cholesterol (CHOL), Low –Density Lipoprotein (LDL), and High-Density
Lipoprotein (HDL), Urea, Creatinine (CREA), and Magnesium (Mg) concentrations by standard
methods. The uthors also collect urine samples for microalbuminuria (MAU) and creatinine tests.
Results: The research results showed that Mg2+ level was lower in DM patients (Mean±SD Mg2+
mg\dl=1.75±0.22), compared to control group (Mean±SDMg2+mg\dl=1.98±0.15).and the different
was statically significant (p=0.000), Mg2+ has shown negative correlation with FBS (r= -0.261,
p=0.033), and with HbA1C (r= -0.142, p=0.003). Also there was a significantly negative
correlation between Mg2+ and MAU(r= -0.445, p=0.000).
Conclusion: In the present study we found a significantly negative correlation between serum
Mg2+ and MAU in diabetic group.